N-glycosylation is usually considered as serum-type glycosylation with sialic acid as terminal monosaccharide. Sialic acid affects absorption, serum half-life and metabolic clearance as well as the physical, chemical (solubility, resistance to proteolysis) and immunogenic properties of glycoproteins.
Sialylation of glycoproteins produced in mammalian cell lines commonly used in biotechnology is often incomplete and there is a need for strategies delivering naturally fully sialylated glycoproteins.
SiaMed’Xpress develops glycoengineered cell lines able to produce glycoproteins with serum-type glycosylation and a high content in sialic acid.
